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  • Title: [Involvement of nitric oxide in the development of tuberculin anergy in patients with pulmonary tuberculosis].
    Author: Sakhno LV, Khonina NA, Norkina OV, Mostovaia GV, Nikonov SD, Ogirenko AP, Chernykh ER, Ostanin AA.
    Journal: Probl Tuberk; 2001; (8):42-6. PubMed ID: 11767392.
    Abstract:
    The production of nitric oxide (NO) and the magnitude of an antigen-specific proliferative response of the human lymphocytes stimulated by M. tuberculosis antigen [a purified protein derivative (PPD)] were investigated. PPD-reactive T lymphocytes were found in the peripheral blood of healthy donors. Normal values (mean values, the range of the minimum and maximum values) of PPD-induced proliferation and NO production were determined. Patients with pulmonary tuberculosis were found to have different levels of PPD-stimulated proliferation and NO production. The lymphocytes are shown to preserve their PPD reactivity in patients with normal NO production whereas the PPD-induced proliferative response was significantly decreased in those with high NO production. Patients with reduced tuberculin reactivities and high NO production were less responsive to treatment. The findings suggest that nitric oxide is involved in the development of tuberculin anergy with pulmonary tuberculosis.
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