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  • Title: Effects of retinoic acid on prostaglandin biosynthesis in guinea-pig skin.
    Author: Ziboh VA, Price B, Fulton J.
    Journal: J Invest Dermatol; 1975 Oct; 65(4):370-4. PubMed ID: 1176787.
    Abstract:
    Topical application of retinoic acid on guinea-pig skin resulted within 70 hours in erythema with a concomitant elevation of endogenous prostaglandin E2 (PGE2) in the treated areas of the skin. Prolonged daily treatment resulted in the development of severe scaly dermatoses and a corresponding decrease in the level of PGE2 in the skin. Examination of retinoic acid effects on the in vitro biosynthesis of PGE2 from arachidonic acid by extracts from guinea-pig skin and sheep vesicular gland demonstrated that retinoic acid inhibits prostaglandin synthesis in a concentration and time-dependent manner. These results indicate that retinoic acid may exert a regulatory role on prostaglandin biosynthesis in the skin.
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