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  • Title: The effect of low oral doses of (-)-deprenyl and its metabolites on DSP-4 toxicity.
    Author: Haberle D, Szökö E, Halász AS, Magyar K.
    Journal: J Neural Transm (Vienna); 2001; 108(11):1239-47. PubMed ID: 11768624.
    Abstract:
    Treatment with a single oral dose of (-)-deprenyl (selegiline) before DSP-4 administration could dose-dependently decrease the noradrenaline (NA) depleting effect of the toxin in mouse hippocampus. The maximum protective effect was achieved at as low oral dose as 0.25 mg/kg. Pre-treatment with the same doses of the main metabolites of (-)-deprenyl; (-)-amphetamine and (-)-methylamphetamine provided a weaker attenuation of DSP-4 induced NA depletion, than the parent compound. The selective noradrenergic toxin DSP-4, which depletes NA in nerve terminals originating from the locus coeruleus, is presumably metabolised by CYP-450 enzymes. Continuous administration of low, by themselves non-toxic doses of DSP-4 resulted in the cumulation of its NA depleting effect.
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