These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The present status of standardization in serum total PSA measurement--a result of "Survey 2000" conducted by PSA ad hoc Committee of Japanese Urological Association].
    Author: Kano S, Ishibashi M, Itoh Y, PSA ad hoc Committee of Japanese Urological Association.
    Journal: Rinsho Byori; 2001 Oct; 49(10):967-73. PubMed ID: 11769473.
    Abstract:
    Immunoassays for serum total PSA are classified into two categories; equimolar and skewed, according to their response to free PSA and ACT-PSA. The analytical survey conducted in 1997 ("Survey 1997") revealed that more than a half of the kits displayed a skewed response which caused inter-assay variability as a major factor. PSA ad hoc committee of Japanese Urological Association chaired by Prof. H. Yamanaka carried out a survey in 2000 ("Survey 2000") in which 26 kits were participated from 18 manufacturers. Comparing with 1997, the inter-kit variability, on the whole, was remarkably reduced in 2000. The dilution tests using purified samples of free PSA and ACT-PSA elucidated that five sixths of the kits were counted to be equimolar (12; completely equimolar, 10; nearly equimolar or slightly skewed, 4; skewed). Immunological behavior of the assays to free PSA and ACT-PSA in serum samples was also markedly improved, in which free PSA content ranged to 50%. Conversion of data measured by each kit to those of Tandem-R was capable in 19 kits. The remaining 7 kits were out of interchangeability, however, a measure of improvement or withdrawal of these kits would be in progress by the corresponding manufacturers. Total PSA assay is certainly going on toward standardization.
    [Abstract] [Full Text] [Related] [New Search]