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  • Title: Selective 5-HT1A receptor agonist, 8-OH-DPAT, locally administered into the dorsal raphe nucleus increased extracellular acetylcholine concentrations in the medial prefrontal cortex of conscious rats.
    Author: Katsu H.
    Journal: Nihon Shinkei Seishin Yakurigaku Zasshi; 2001 Oct; 21(4):121-3. PubMed ID: 11769569.
    Abstract:
    The effects of a selective 5-hydroxytryptamine (5-HT)1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), directly administered into the dorsal raphe nucleus (DR) on acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) of freely moving rats were investigated by using a microdialysis technique. 8-OH-DPAT (1.0 and 5.0 micrograms) administered into DR significantly increased extracellular ACh concentrations in mPFC in a dose-dependent manner with a maximal increase to 215% and 237% of basal level, respectively, whereas a 0.1 microgram dose of this drug failed to exert such an increase. The present study suggests that the stimulation of somatodendritic 5-HT1A autoreceptors in DR is involved in an enhancement in ACh release in mPFC.
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