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  • Title: [Cytokine networks and their endogenous modulators in patients with congestive heart failure].
    Author: Yang L, Zhu S, Wang X.
    Journal: Zhonghua Nei Ke Za Zhi; 2001 Oct; 40(10):660-2. PubMed ID: 11769717.
    Abstract:
    OBJECTIVE: To explore the pathophysiological role of cytokine network and their endogenous modulators in the development of congestive heart failure (CHF). METHODS: Plasma levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6(IL-6), soluble TNF receptor I (sTNF-RI) and transforming growth factor (TGF)-beta were measured by enzyme-linked immunoassay in 52 CHF patients with various degrees of heart failure and in 30 healthy controls. RESULTS: Patients with CHF had increased plasma concentrations of TNF alpha, IL-6 and sTNF-RI, but decreased levels of TGF-beta. They also had elevated ratios of TNF-alpha/sTNF-RI and TNF-alpha/TGF-beta, particularly those in functional class IV. The levels of TNF-alpha were positively correlated with IL-6 and sTNF-RI but negatively correlated with TGF-beta(P < 0.01). CONCLUSIONS: The imbalance in the cytokine network were most pronounced in patients with the most severe heart failure. CHF may be accompanied by a shift toward enhanced levels of inflammatory cytokines combined with inadequately raised or even decreased levels of anti-inflammatory cytokines. A poorly regulated cytokine network may be involved in the development and progression of CHF.
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