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  • Title: [Critical role for cell cycle regulators in androgen receptor function].
    Author: Akita H, Hashimoto Y, Hibino M, Iizuka A, Kohri K.
    Journal: Hinyokika Kiyo; 2001 Nov; 47(11):819-23. PubMed ID: 11771178.
    Abstract:
    Androgen plays an important role in the growth of prostate cancer, but the molecular mechanism that underlies development of resistance to antiandrogen therapy remains unknown. Cyclin E has now been shown to increase the transactivation activity of the human androgen receptor (AR) in the presence of its ligand dihydrotestosterone. The enhancement of AR activity by cyclin E was resistant to inhibition by the antiandrogen 5-hydroxyflutamide. Cyclin E was shown to bind directly to the AB domain of the AR, and to enhance its AF-1 transactivation function. These results suggest that cyclin E functions as a coactivator of the AR, and that aberrant expression of cyclin E in tumors may contribute persistent activation of AR function, even during androgen ablation therapy.
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