These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Reverse in situ hybridization of DNA probes of anomalous chromosomes in diagnosing chromosome pathologies].
    Author: Rubtsov NB, Karamysheva TV, Matveeva VG, Sablina OV, Sosnitskaia SV, Andreenkova OV, Gaĭner TA, Degtiareva MM.
    Journal: Genetika; 2001 Nov; 37(11):1545-52. PubMed ID: 11771310.
    Abstract:
    The results of analysis of congenital chromosomal pathologies and chromosomal rearrangements upon the occurrence of haematological diseases, which was involved constructing DNA libraries of abnormal chromosomes and subsequent reverse CISS hybridization have been considered. High effectiveness of this approach for analysis of chromosomal translocations, deletions of chromosomal regions, minor extra chromosomes, and large marker chromosomes with complex organization was shown. The possibility of implementation of this approach and its large-scale application in medical and genetic studies of congenital developmental pathologies and chromosomal diagnostics of haematological diseases has been discussed.
    [Abstract] [Full Text] [Related] [New Search]