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  • Title: [The association between A1166-->C of angiotensin II type 1 receptor gene and pregnancy induced hypertension].
    Author: Hu Y, Bi Y, Guan G.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 2000 Mar; 35(3):136-8. PubMed ID: 11775887.
    Abstract:
    OBJECTIVE: To determine the distribution of gene type of A1166 polymorphism site of the angiotensin II type 1 receptor gene (AT1RG) and whether it might be implicated in pregnancy induced hypertension (PIH) woman. METHODS: We used polymerase chain reaction (PCR), restriction enzyme analysis and electrophoresis for this study. RESULTS: 1. The gene types of A1166 polymorphism site of AT1R gene on normal control and PIH and essential hypertension subjects were in accordance with Hardy-Weinberg laws. 2. The C allele frequencies of AT1R gene (A1166-->C) in control, PIH, and essential hypertension subjects was 3.7%, 11.4%, and 9.4%, respectively. 3. The frequency of variants(AC, CC) of AT1R gene A1166 polymorphism site in PIH (20.5%) was significantly higher than that of control subjects (7.4%). 4. The gene type of variants (AC, CC) and C allele frequency of AT1R gene A1166 polymorphism site in essential hypertension (18.8%, 9.4%, respectively) was higher than those of control subjects. There is no statistical difference in A1166-->C variants between PIH and essential hypertension. CONCLUSIONS: 1. The variants(A-->C) of 1166 polymorphism site of AT1RG predisposes increased risk of PIH. 2. The PIH patients are at the risk of suffering from essential hypertension.
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