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  • Title: [Serum lipoprotein(a) in woman with pregnancy induced hypertension].
    Author: Zhao Y, Tang H, Liu S.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 2000 Mar; 35(3):145-7. PubMed ID: 11775890.
    Abstract:
    OBJECTIVE: To examine lipoprotein(a) level in woman with Pregnancy induced hypertension (PIH) to elucidate the effect of it on the pathogenesis of the disease. METHODS: Serum lipoprotein (a) total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels were measured in 20 normal pregnant woman (control group) and 32 pregnant woman with PIH (PIH group). The PIH group was further divided into the following subgroup: mild, moderate, and severe PIH. We used a transmission turbidimetry method to measure serum lipoprotein(a). RESULTS: (1) The serum lipoprotein (a) levels were higher in PIH group than that in control group (228 +/- 187 mg/L vs 106 +/- 93 mg/L). (2) The serum lipoprotein (a) levels were higher in all PIH subgroups than that in control. (3) The serum levels of TC, TG, LDL-C in the PIH group were higher than those in control, while the level of HDL-C in the PIH group was lower than that in control (0.98 +/- 0.16 mmol/L vs 1.09 +/- 0.17 mmol/L). CONCLUSIONS: This study has demonstrated that lipoprotein (a) levels are elevated in pregnant woman with PIH and associated with severity of the disease. It may involved in the pathogenesis of PIH.
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