These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Detection and significance of interleukin-16 in sputa from patients with bronchial asthma].
    Author: Shi H, Liu G, Chen Y.
    Journal: Zhonghua Jie He He Hu Xi Za Zhi; 1999 Apr; 22(4):224-7. PubMed ID: 11775918.
    Abstract:
    OBJECTIVE: To explore the significance of in the terleukin-16 (IL-16) in pathogenesis of bronchial asthma. METHODS: Induced sputum samples were obtained from 12 allergic asthmatics, 8 non-allergic asthmatics, 10 non-asthma allergic and 10 non-asthma non-allergic normal subjects. ELISA was used to determine the concentrations of IL-16 in sputum, and CD4+ T cells and activated eosinophils (EG2 cells) in sputum were detected by immunostaining. RESULTS: IL-16 levels in both allergic and non-allergic asthmatics were much higher than those in non-asthma allergic or non-asthma non-allergic normal subjects. Effective anti-asthma treatment led to a significant decrease in IL-16 levels in patients with acute asthma. It was also found that the percentages of CD4+ and EG2 cells were all positively correlated to IL-16 levels. CONCLUSIONS: IL-16 is involved in the asthmatic process by recruiting CD4+ T cells and thus plays an important role in CD4+ cell-dependent eosinophilic inflammation in asthmatic airways.
    [Abstract] [Full Text] [Related] [New Search]