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  • Title: Effect of anti-P-selectin monoclonal antibody on renal ischemia/reperfusion injury in rats.
    Author: Zhou T, Li X, Wu P, Zhang D, Zhang M, Chen N, Dong D.
    Journal: Chin Med J (Engl); 2000 Sep; 113(9):790-3. PubMed ID: 11776071.
    Abstract:
    OBJECTIVE: To explore the effect of anti-P-selectin monoclonal antibody (mAb) on renal ischemia/reperfusion (I/R) injury in rats. METHODS: Renal function, renal histopathological changes, plasma P-selectin levels and renal P-selectin protein and mRNA expression were studied in a renal I/R injury rat models. Biochemical measurement, ELISA, Immunohistochemistry and Nested RT-PCR were used. RESULTS: Renal function insufficiency and renal histopathological damage were much less in the anti-P-selectin mAb-treated group than the saline-treated group. Plasma P-selectin levels were lower and renal P-selectin protein and mRNA expression were down-regulated in the former group. CONCLUSION: Anti-P-selectin mAb might be an efficient approach for the treatment of renal I/R injury.
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