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  • Title: [Effect of tamoxifen on apoptosis and drug resistance of breast cancer cells in vitro].
    Author: Zheng J, Yao Z.
    Journal: Zhonghua Zhong Liu Za Zhi; 2000 Jan; 22(1):55-7. PubMed ID: 11776601.
    Abstract:
    OBJECTIVE: To study the effect of estradiol (E2) and tamoxifen (TAM) on the apoptosis regulatory genes (bax, bcl-2) and mdr-1 in MCF-7 cells. METHODS: Immunohistochemistry, in situ hybridization were used to observe the changes in bax, bcl-2 and mdr-1 genes after treatment with E2 and TAM. RESULTS: E2 had ability to increase the expression of bcl-2 and mdr-1 but TAM decrease the expression of both. Synthetic bax oligodeoxynucleotide (ODN) was used as probe to perform in situ hybridization. It was shown that bax mRNA in MCF-7 cells was down-regulated by E2 and up-regulated by TAM. Significant correlation between bcl-2 and mdr-1 was observed after TAM treatment of MCF-7 cells (P < 0.05). CONCLUSION: TAM regulates cell apoptosis and inhibits development of drug-resistance of MCF-7 breast cancer.
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