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  • Title: [Study on factors influencing survival in patients with cancer of the esophagus after resection by Cox proportional hazard model].
    Author: Zhang H, Ping Y, Du X.
    Journal: Zhonghua Zhong Liu Za Zhi; 1999 Jan; 21(1):32-4. PubMed ID: 11776792.
    Abstract:
    OBJECTIVE: To study the prognostic factors in patients with cancer of the esophagus after curative resection. METHODS: From 1985 to 1989 in our hospital, 1014 patients operated on for neoplasia of esophagus, who underwent a curative resection, and did not die within 30 days or during the hospital stay after operation, were included in this study. Thirteen possible factors influencing survival were selected. A multivariate analysis of these individual variables was performed using the cumulative survival rate by the computer's Cox proportional hazard model. RESULTS: The follow-up rate was 91.9% over 5 years. The over-all cumulative survival rate was 54.9% at 3 years, 45.9% at 5 years, and 39.3% at 10 years. The results showed that the major significant prognostic factors influencing survival of these patients were lymph node metastases, TNM stage, depth of invasion, location of tumor and histologic type (P < 0.0001). CONCLUSION: Lymph node metastasis is the most important prognostic factor for cancer of esophagus after curative resection. Lymphadenectomy along with esophagectomy is necessary to improve survival rate.
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