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  • Title: [Study of microsatellite instability of colotectal cancer and its clinical significance].
    Author: Xiong B, Zheng S, Cai X.
    Journal: Zhonghua Zhong Liu Za Zhi; 1999 May; 21(3):199-201. PubMed ID: 11776835.
    Abstract:
    OBJECTIVE: To evaluate microsatellite instability (MI) of colorectal cancer in China. METHOD: Replication error (RER) status was examined by using 6 microsatellite loci D2S123, D2S119, D13S160, D8S282, D3S1293 and D18S58. The loci were amplified by PCR technique. The PCR products were separated on denatured polyacrylamide gel and then silver stained. RESULTS: Of the 60 cases of colorectal cancer studied, 20 (33.3%) showed MI, 11 cases (18.3%) were RER positive. In 11 RER-positive cases, 4(36.4%) had family history of malignant tumor, while only 8.2% had positive family history in RER-negative cases (P < 0.05). The RER-positive patients were younger, and their cancer occurred more frequently in the colon with invasive type of growth. There were more cancers in Dukes III and IV in the REF-positive patients. In 5 colorectal cancer cases associated with adenoma, MI was detectable in 4 adenomas. CONCLUSION: MI phenotype might be present ubiquitously in sporadic colorectal cancers in China. Its frequency is comparable to that of other reports. MI is a relatively early molecular event in the genesis of colorectal cancers. RER is a useful sign of susceptibility to the development of colorectal cancer.
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