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  • Title: [The abnormal expression of pRb during DMBA-induced hamster buccal pouch carcinogenesis].
    Author: Duan K, Chen Q, Li B.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 1999 Jul; 34(4):234-5. PubMed ID: 11776915.
    Abstract:
    OBJECTIVE: To study the expression and role of pRb in 7,12-dimethylbenzanthracene(DMBA) induced hamster buccal pouch carcinogenesis. METHODS: DMBA (0.5%) in acetone was applied to the right buccal pouch 3 times per week for up to 12 week. Paraffin-embedded sections were used for pRb immunohistochemical determination (ISAB technipue, polyclonal antibody c-15 for pRb). The density of staining was analysed by rank sum test. RESULTS: The positive staining of pRb was strong in normal buccal epithelium, no alteration of pRb staining in 3 week (hyperplastic epithelium) and somewhat reduced between 6 and 9 week (dysplastic lesion), but it was marked reduced in 12 week (carcinoma). Statistical analysis found that changes of pRb were associated with stages of carcinogenesis. CONCLUSION: These results indicate that abnomal expression of Rb gene product could be related to oral carcinogenesis and may serve as a biomarker for supervising oral malignancy.
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