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  • Title: [Effects of endothelin-1 on the collagen synthesis of cultured human dental pulp cells].
    Author: Yan Y, Liu Z.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 1999 May; 34(3):162-4. PubMed ID: 11776930.
    Abstract:
    OBJECTIVE: To study the effects of endothelin-1(ET-1) on the collagen synthesis of cultured human dental pulp cells. METHODS: Cell cultured, enzyme linked immmun sorbent assay (ELISA), and ABC immunhistochemical staining were used in the study. RESULTS: ET-1 increased the synthesis of soluble type I collagen in different periods besides the 24 h group, and had no effects on the type III collagen; immunohistochemical staining revealed that ET-1 also increased the synthesis of unsoluble type I collagen. CONCLUSION: ET-1 can stimulate type I collagenic synthesis of human dental pulp cells and might have an effect on pulp self-restoration.
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