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  • Title: Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein.
    Author: Masri B, Lahlou H, Mazarguil H, Knibiehler B, Audigier Y.
    Journal: Biochem Biophys Res Commun; 2002 Jan 11; 290(1):539-45. PubMed ID: 11779205.
    Abstract:
    We report here that apelin (65-77) induces activation of extracellular-regulated kinases (ERKs) in Chinese hamster ovary (CHO) cells expressing the msr/apj receptor. This concentration-dependent activation was transient, peaking at 5 min. Pretreatment of CHO cells with pertussis toxin fully abrogated ERK phosphorylation, whereas overexpression of the beta-adrenergic receptor kinase-1 C-terminal fragment did not alter ERK activation. Transfection with a dominant-negative mutant of Ras was without effect on ERK activation, whereas an inhibitor of many protein kinase C isoforms, GF109203X, strongly decreased it. These results demonstrate that stimulation of the murine msr/apj receptor promotes ERK activation via the alpha subunit of a pertussis toxin-sensitive protein in a Ras-independent pathway.
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