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  • Title: Involvement of presynaptic N-methyl-D-aspartate receptors in cerebellar long-term depression.
    Author: Casado M, Isope P, Ascher P.
    Journal: Neuron; 2002 Jan 03; 33(1):123-30. PubMed ID: 11779485.
    Abstract:
    At the cerebellar synapses between parallel fibers (PFs) and Purkinje cells (PCs), long-term depression (LTD) of the excitatory synaptic current has been assumed to be independent of the N-methyl-D-aspartate (NMDA) receptor activation because PCs lack NMDA receptors. However, we now report that LTD is suppressed by NMDA receptor antagonists that act on presynaptic NMDA receptors of the PFs. This effect is still observed when the input is restricted to a single fiber. Therefore, LTD does not require the spatial integration of multiple inputs. In contrast, it involves a temporal integration, since reliable LTD induction requires the PFs to fire two action potentials in close succession. This implies that LTD will selectively depress the response to a burst of presynaptic action potentials.
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