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  • Title: [Titer and avidity of serum antibody to Porphyromonas gingivalis before and after periodontal therapy].
    Author: Ouyang X, Cao C, Chen Z.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2000 May; 35(3):188-90. PubMed ID: 11780220.
    Abstract:
    OBJECTIVE: To observe the changes of titer and avidity of serum antibody to Porphyromonas gingivalis (Pg) before and one month after periodontal therapy, and to observe the correlation of titer and avidity of anti-Pg IgG with clinical indices. METHODS: ELISA and DEA-ELISA were used to determine the titer and avidity of serum IgG antibody to Pg381 before and one month after periodontal treatment in 17 periodontitis patients and 6 healthy control subjects. RESULTS: The titers of anti-Pg IgG antibody were higher in periodontitis patients than in healthy control subjects (P < 0.001). All patients were seropositive (titers to Pg were higher than 2-fold above the median for control subjects). IgG antibody avidity to Pg in periodontitis patients were not found to be significantly lower than that in control group. The titers to Pg decreased significantly at one month after periodontal therapy, but antibody avidity didn't change. Serum anti-Pg antibody titers had a tendency of negative correlation with probing depth. The antibody titers were significant higher in periodontitis patients with < or = 5 mm mean probing depth than in patients with > 5 mm mean probing depth. CONCLUSIONS: It is suggested that the humoral immune response to Pg381 is protective and this protective effect mainly depends on the titer of antibody.
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