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  • Title: Analysis of hypermutation of the 5' noncoding region in the BCL-6 gene.
    Author: Wang L, Xu L, Jin X, Liu J, Huang W, Wang H, Wang J, Gu B, Yang W, Liu H, Chen Z, Chen S.
    Journal: Chin Med J (Engl); 2001 Mar; 114(3):286-90. PubMed ID: 11780315.
    Abstract:
    OBJECTIVE: To investigate BCL-6 gene mutations in Chinese populations with B-cell non-Hodgkin's lymphoma. METHODS: Polymerase chain reaction (PCR), denaturing gradient gel electrophoresis (DGGE) and direct DNA sequencing were used to identify mutations in the 5' noncoding region of the BCL-6 gene in a total of 40 cases of diffuse large-cell lymphoma (DLCL) and follicular lymphoma (FL). RESULTS: Nine cases were found to have base substitutions. The incidence of BCL-6 gene mutation and the frequency of single-base changes were approximately 25.7% and (0.56-1.10) x 10(-2)/bp, respectively. CONCLUSIONS: The 5' regulatory region of the BCL-6 gene undergoes frequent somatic hypermutation during lymphomagenesis and the identification of BCL-6 gene hypermutations provides a molecular marker for confirmatory diagnosis of B-NHL.
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