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  • Title: [Noxious stimulation-induced morphological changes of nitric oxide synthase-positive neurons in the tongue of rats].
    Author: Shao J, Xin G, Yang H.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2000 Mar; 35(2):144-6. PubMed ID: 11780489.
    Abstract:
    OBJECTIVE: To explore noxious stimulation-induced morphological changes of nitric oxide synthase (NOS) positive neurons in the tongue. METHODS: The histochemical method of reduced nicotinamide adenine dinucleotide phosphate(NADPH)-diaphorase activity was used. RESULTS: NOS positive neuron bodies in the tongue were obviously enlarged, the staining intensity increased and nerve fibers became thicker after injury. At the body and tip of the tongue, near the body cells of NOS positive neurons deeply stained fine granular particles were seen, and structures of plum blossom form were seen along the route of the nerve fiber extending all the way to the terminal. NOS positive nerve fibers in the striated muscles and around the gland in the tongue root became thicker, and bead structures were seen in some of the fibers. CONCLUSION: NOS positive neurons of the tongue, when noxiously stimulated, are inflicted with pathological changes, which suggest that nitric oxide might play a role in the transmission and control of the message related to pathological lesions.
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