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  • Title: Systemic tumor suppression by the proapoptotic gene bik.
    Author: Zou Y, Peng H, Zhou B, Wen Y, Wang SC, Tsai EM, Hung MC.
    Journal: Cancer Res; 2002 Jan 01; 62(1):8-12. PubMed ID: 11782349.
    Abstract:
    Metastatic breast cancer requires systemic treatment. We have developed a systemic gene therapy approach for breast cancer, consisting of a nonviral gene delivery system (SN) and a proapoptotic gene, bik. The transfection efficiency of SN carrying a reporter gene was 5-10 times higher than the common nonviral agents Fugene-6 and Lipofectamine in the presence of serum. The SN-bik gene complex induced significant apoptosis in four breast cancer cell lines in vitro as well as in orthotopic tumor tissues in nude mice. Systemically administrated SN-bik significantly inhibited the growth and metastasis of human breast cancer cells implanted in nude mice and prolonged the life span of the treated animals. This study demonstrates that SN-bik is a promising approach for further development as a potential therapeutic agent of cancer.
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