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  • Title: [Telomerase activity of common malignant tumors].
    Author: Liu X, Zou Y, Guo C.
    Journal: Zhonghua Zhong Liu Za Zhi; 2001 Jan; 23(1):25-7. PubMed ID: 11783063.
    Abstract:
    OBJECTIVE: To study the usefulness of detection of telomerase activity in the diagnosis of malignant tumors. METHODS: Modified telomeric repeat amplification protocol (TRAP) was employed to examine telomerase activity in 283 malignant tumor tissues, 42 adjacent tissues and 61 benign tumor tissues. RESULTS: Of the 283 malignant tumors and 42 adjacent tissues, telomerase was positive in 264 (93.3%) and 11 (26.1%), respectively. Only 4 of the 62 (6.6%) benign tumors were telomerase positive. CONCLUSION: Telomerase activity may be used as tumor marker in the diagnosis of malignant tumors.
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