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  • Title: [Expression of VEGF, bFGF and ER in endometrial carcinoma].
    Author: Bai X, Mi R.
    Journal: Zhonghua Zhong Liu Za Zhi; 2001 May; 23(3):211-3. PubMed ID: 11783088.
    Abstract:
    OBJECTIVE: To investigate the expression of VEGF, bFGF and ER in endometrial carcinoma and its relation to the clinico-pathological manifestations and prognosis. METHODS: A total of 66 specimens of endometrial carcinoma and 19 normal endometrium was studied by immunohistological technique with polyclonal antibodies against VEGF and bFGF, and monoclonal antibody against ER. RESULTS: Positive expression rate of VEGF in endometrial carcinoma was 80.3%. Expression of VEGF was positively correlated with tumor grade (P < 0.01). Expression of VEGF was positively correlated with that of bFGF (P < 0.05). Negative correlation was observed between ER expression and tumor grade (P < 0.05). Prognosis of patients with negative ER expression was poor. No correlation existed between ER expression and that of VEGF and bFGF. CONCLUSION: Expression of VEGF and bFGF may indicate that both of them contribute in the angiogenesis of endometrial carcinoma. Expression of ER has prognostic significance.
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