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  • Title: [Relationship between follicular development and insulin like growth factor I receptor in stimulated cycles].
    Author: Chen D, Shi Y, Chen H.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 2001 Feb; 36(2):98-100. PubMed ID: 11783357.
    Abstract:
    OBJECTIVE: To investigate the number of follicles and insulin-like growth factor I receptor (IGF-I R) in stimulated cycles. METHOD: IGF-I R mRNA and IGF-I R in granulosa cells obtained during oocyte retrieval were respectively measured by reverse transcript polymerase chain reaction (RT-PCR) and Western blot technique. RESULTS: The expression of IGF-I R mRNA in poor responders (follicles < or = 3) was much lower than in normal responders (follicles 4-13) and high responders (follicles > or = 14) (1.70 +/- 0.23, 2.92 +/- 0.49, 4.22 +/- 1.50 respectively). Similar results were obtained for IGF-I R (1.32 +/- 0.31, 2.01 +/- 0.72, 4.39 +/- 2.31 respectively). CONCLUSION: The expression of IGF-I R correlated with the effects of gonadotropin hormone on follicular development.
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