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  • Title: [Correlation of the metabolism of oxygen free radical in ovary, uterine muscle and vein blood with the pathogenesis of endometriosis or endometrioma].
    Author: Zhao L, Zhao W, Ou Y.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 2001 May; 36(5):299-301. PubMed ID: 11783383.
    Abstract:
    OBJECTIVE: To investigate the correlation of metabolism disturbance of oxygen free radical (OFR) with endometriosis and endometrioma, to provide an evidence for the diagnosis and treatment. METHODS: (1) The lipid peroxide (LPO), selenium (Se), superoxide dismutase (SOD) and vitamin E (VE) levels were respectively in the vein blood, ovary tissue of the chocolate cyst wall and chocolate cyst fluid in 32 operated patients with endometriosis (endometriosis group). (2) The levels above were determined separately in 23 operated patients with endometrioma (endometrioma group) and 30 cases of hysteroma (control group). RESULTS: (1) The LPO levels in vein blood and ovary tissue of endometriosis group were (6.357 +/- 1.251) mumol/L and (3.735 +/- 1.546) nmol/g protein. Which significantly higher than those of control group (P < 0.01). On the other hand, the Se. SOD. VE levels in endometriosis group were significantly lower than those in control group (P < 0.01-< 0.05). (2) The LPO level in ovary chocolate cyst fluid was higher than that in vein blood itself and control group. (P < 0.01). (3) The LPO levels in vein blood and uterine muscle of endometrioma was (5.882 +/- 1.711) mumol/L and (2.937 +/- 1.577) nmol/g protein, they were higher-than these in control group (3.547 +/- 1.640) mumol/L, (1.754 +/- 0.833) nmol/g protein, (P < 0.01). While, the Se. VE. SOD level tween the SOD level in uterine muscle tissue of endometriomin vein blood is significantly higher than those in control group (P < 0.01). There is no difference bea and control group (P > 0.05). CONCLUSION: The endome triosis and endometrioma is related to the produce or metabolistic imbalance of oxygen free radical, and so to the increasing of lipid peroxide.
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