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  • Title: Role of changes in the pulsatile secretion pattern of FSH in initiation of ovarian folliculogenesis in bitches.
    Author: Kooistra HS, Okkens AC.
    Journal: J Reprod Fertil Suppl; 2001; 57():11-4. PubMed ID: 11787137.
    Abstract:
    The results of two studies in which the pulsatile secretion patterns of LH and FSH were investigated in six Beagle bitches during early, mid- and late anoestrus and in six anoestrous Beagle bitches treated with bromocriptine are summarized to improve our knowledge of the endocrine changes that lead to a new follicular phase in bitches. Blood samples for the determination of secretory profiles were obtained via jugular venepuncture at 10 min intervals for 6 h. In untreated bitches, blood samples were collected during early, mid- and late anoestrus. In bromocriptine-treated bitches (20 micrograms kg-1 twice each day, starting 100 days after ovulation until the start of the next oestrous cycle), blood samples were collected before treatment and at 2 week intervals after the start of bromocriptine treatment until the next ovulation. In all bitches, FSH and LH were secreted in a pulsatile manner and FSH pulses coincided with LH pulses. Progression from early to late anoestrus was associated with an increase in FSH secretion without a concomitant increase in LH secretion. The bromocriptine-induced shortening of the interoestrous interval was also associated with an increase in FSH secretion without a concomitant increase in LH secretion. These results indicate that in bitches an increase in circulating FSH should be considered to be a critical event required for the initiation of ovarian folliculogenesis and consequently the termination of anoestrus.
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