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  • Title: Hypoxic sensitizers: radiobiological studies at the cellular level.
    Author: Hall EJ, Roizin-Towle L.
    Journal: Radiology; 1975 Nov; 117(2):453-7. PubMed ID: 1178881.
    Abstract:
    The nitroimidazoles have been found to selectively sensitize hypoxic cells to the effects of irradiation. The latest in this family of drugs is RO-07-0582, which is able to mimic 80% of the oxygen effect at a concentration of 5 mM by modifying the sensitivity of hypoxic cells to single doses of gamma rays; however, it is not a substitution for oxygen in promoting the repair of sublethal radiation damage between split doses. Studies show that it is a powerful cytotoxic agent as well and selectively operates against hypoxic cells.
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