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  • Title: [Observation on dynamic changes of serum procollagen III, hyaluronic acid and laminin in rats with hepatic fibrosis treated with Hujin pill].
    Author: Huang Z, Li Q, Wang Z.
    Journal: Zhongguo Zhong Xi Yi Jie He Za Zhi; 2000 Jun; 20(6):447-9. PubMed ID: 11789232.
    Abstract:
    OBJECTIVE: To study the dynamic changes of serum procollagen III (PCIII), hyaluronic acid (HA) and laminin (LN) in rats with hepatic fibrosis treated with Hujin pill (HJP). METHODS: The classic model of hepatic fibrosis induced by CCl4 were used in the observation. The serum PCIII, HA and LN were determined by radioimmunoassay (RIA). RESULTS: HJP could reduce the serum HA, LN content significantly, as compared with the control group, the difference was significant (P < 0.05, P < 0.01). Its long-term therapeutic effect was better than that of colchicine. It could maintain the serum PCIII stable in hepato-fibrotic stage (9-12 weeks), as compared with the normal control group, the difference was insignificant (P > 0.05). CONCLUSION: HJP could retard the liver fibrosis, and has good preventive and therapeutic effect on liver fibrosis in rats.
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