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  • Title: Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension.
    Author: Jiang Z, Zhao W, Yu F, Xu G.
    Journal: Chin Med J (Engl); 2001 Dec; 114(12):1249-51. PubMed ID: 11793845.
    Abstract:
    OBJECTIVE: To determine whether the polymorphism A1166C in the angiotensin II type 1 receptor (AT1R) gene is associated with essential hypertension. METHODS: A case-control study was carried out using 125 hypertensive and 103 normotensive subjects. The A-->C variant at position 1166 (A1166C) of the AT1R gene was identified by polymerase chain reaction (PCR) and PCR/restriction fragment length polymorphism (PCR/RFLP) analysis. The digestion products were separated on 2% agarose gels and visualized with ethidium bromide under ultraviolet ray. RESULTS: The differences in C1166 allele frequency and in the AC genotype distribution of the AT1R gene between the hypertensive and normotensive groups were statistically significant (C allele: 0.092 vs 0.034, chi 2 = 6.186, P < 0.05; AC genotype: 0.184 vs 0.068, chi 2 = 6.654, P < 0.05). CONCLUSION: The AC genotype is associated with essential hypertension, and the C allele may be a marker for predisposition to hypertension in Chinese Han population.
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