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  • Title: [Why does nitroglycerin tolerance appear?].
    Author: Włodek L, Sokołowska M.
    Journal: Postepy Hig Med Dosw; 2001; 55(5):673-85. PubMed ID: 11795202.
    Abstract:
    Nitroglycerin (NTG) and other organic nitrates are beneficial drugs for the treatment of acute forms of coronary artery disease. The major limitation of organic nitrates use in clinical practice is the rapid development of hemodynamic tolerance. In general mechanisms of tolerance can be categorized into two different groups. One group of mechanisms is related to changes in the vascular smooth muscle bioactivation of organic nitrates. The other mechanisms are related to physiological response to increase nitric oxide (NO) production.
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