These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Inhibition of cyclooxygenase-2: an approach to preventing cancer of the upper aerodigestive tract.
    Author: Dannenberg AJ, Altorki NK, Boyle JO, Lin DT, Subbaramaiah K.
    Journal: Ann N Y Acad Sci; 2001 Dec; 952():109-15. PubMed ID: 11795429.
    Abstract:
    Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2), an inducible form of COX, represents a potential pharmacologic target to prevent cancer. Key data suggesting a causal relationship between increased COX-2 activity and carcinogenesis and possible mechanisms of action of COX-2 in this context will be discussed. The possibility that COX-2 represents a pharmacological target for preventing upper aerodigestive cancers (head and neck, lung) will be emphasized. Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors.
    [Abstract] [Full Text] [Related] [New Search]