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  • Title: 2'-Deoxyguanosine (DG) oxidation and strand-break formation in DNA by the radicals released in the photolysis of N-tert-butoxy-2-pyridone. Are tert-butoxyl or methyl radicals responsible for the photooxidative damage in aqueous media?
    Author: Adam W, Marquardt S, Kemmer D, Saha-Möller CR, Schreier P.
    Journal: Org Lett; 2002 Jan 24; 4(2):225-8. PubMed ID: 11796056.
    Abstract:
    [reaction: see text] The photolysis of pyridone 3b (photo-Fenton reagent) in benzene releases tert-butoxyl radicals, which have been trapped by DMPO and EPR-spectrally identified. In aqueous solution, however, the fragmentation of the tert-butoxyl into methyl radicals prevails and the former radicals are of no direct consequence in the photooxidation of 2'-deoxyguanosine (dG) and pBR 322 DNA. The photooxidative damage of nucleic acids is caused by the oxyl radical species generated from the methyl radicals with oxygen.
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