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  • Title: Successful treatment of metastatic hormone-refractory prostate cancer with malignant pericardial tamponade using docetaxel.
    Author: Hayes-Lattin BM, Kovach PA, Henner WD, Beer TM.
    Journal: Urology; 2002 Jan; 59(1):137. PubMed ID: 11796304.
    Abstract:
    Reports of malignant pericardial effusion due to adenocarcinoma of the prostate are few and describe only patients with hormone-naive disease. We report a case of malignant pleural and pericardial effusions due to metastatic hormone-refractory prostate cancer. Despite presenting with pericardial tamponade, this patient was successfully treated with pericardiocentesis and intrapericardial methylprednisolone and cisplatin, followed by a course of intravenous docetaxel. The patient was alive and free of disease-related symptoms nearly 2 years later. This case suggests that patients with pericardial tamponade due to hormone-refractory prostate cancer do not have a uniformly dismal prognosis and should be considered for aggressive treatment.
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