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  • Title: Azole cross-resistance in Aspergillus fumigatus.
    Author: Mosquera J, Denning DW.
    Journal: Antimicrob Agents Chemother; 2002 Feb; 46(2):556-7. PubMed ID: 11796377.
    Abstract:
    We susceptibility tested 17 clinical isolates of Aspergillus fumigatus, for most of which MICs of itraconazole were elevated (MIC at which 50% of the isolates tested are inhibited, 16 microg/ml), against itraconazole, posaconazole, ravuconazole, and voriconazole. Posaconazole was the most active against itraconazole-susceptible isolates. A complex pattern of cross-resistance and hypersusceptibility was seen with voriconazole and ravuconazole, suggesting marked differences in activity and mechanisms of resistance.
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