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  • Title: [The expression and clinical significance of proliferative antigen Ki-67 and apoptosis-antagonizing antigen Bcl-2 in non-Hodgkin's lymphoma].
    Author: Xu W, Sheng R, Zheng Z, Xu T.
    Journal: Zhonghua Nei Ke Za Zhi; 2001 Jul; 40(7):452-5. PubMed ID: 11798613.
    Abstract:
    OBJECTIVE: To evaluate the expression of proliferative antigen Ki-67 and apoptosis-antagonizing protein Bcl-2 as well as their clinical significance in non-Hodgkin's lymphoma (NHL). METHODS: Ki-67 antigen and Bcl-2 protein were measured by immunohistochemistry on paraffin -embedded slices in 35 cases of NHL. RESULTS: (1) The level of Ki-67 expression in low grade NHL was lower than that in high grade NHL (P < 0.01),while Bcl-2 expression in lower grade NHL was higher than that in high grade (P < 0.01). (2) The level of Bcl-2 expression in B cell NHL was higher than that in T cell NHL (P < 0.02), but there was no difference in the expression of Ki-67. (3) The level of Bcl-2 expression in remission group was lower than that in non-remission group after the first course of chemotherapy, but there was no significant difference in Ki-67 expression. (4) The survival time was longer in the group with Ki-67 < or = 20% than that in the group with Ki-67 > 20%, but there was no significant difference of survival time between the high and low expression group of Bcl-2. CONCLUSIONS: The level of Ki-67 and Bcl-2 expression was closely related with the grade of malignant and the prognosis of NHL. They were a pair of useful markers for understanding the generation and prognosis of NHL.
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