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  • Title: [The effect of memory T lymphocytes on IgE production by B lymphocytes in patients with bronchial asthma].
    Author: Han S, Huang J, An D, Li Q.
    Journal: Zhonghua Nei Ke Za Zhi; 1999 Feb; 38(2):101-3. PubMed ID: 11798635.
    Abstract:
    OBJECTIVE: To study the role of CD(4)(+) CD(45)RO(+) T lymphocytes in the pathogenesis of bronchial asthma. METHODS: CD(4)(+) CD(45)RO(+) T lymphocyte subsets were isolated from peripheral blood of patients with bronchial asthma and healthy donors. Then they were cultured with self-B lymphocytes and designated as pokeweed mitogen (PWM)-stimulated and non-stimulated group. Secreted IgE was measured in the supernatant. RESULTS: CD(4)(+) CD(45)RO(+) T lymphocytes had a positive role on IgE production by B lymphocytes from patients of bronchial asthma in non-stimulated group, but the positive role did not exit in the presence of PWM. The effect of activated and non-activated CD(4)(+) CD(45)RO(+) T lymphocytes from patients with bronchial asthma on the secretion of IgE by B lymphocytes were further investigated. CONCLUSION: The function of activated CD(4)(+) CD(45)RO(+) T lymphocytes returned to normal level. It is suggested that CD(4)(+) CD(45)RO(+) T lymphocytes have adverse effects on IgE production in patients with bronchial asthma; which may be related to the pathogenesis of asthma.
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