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  • Title: [Bioavailability of three brands of omeprazole capsule and their effects on 24 hour intragastric pH in healthy volunteers].
    Author: Dong H.
    Journal: Zhonghua Nei Ke Za Zhi; 1999 Aug; 38(8):533-6. PubMed ID: 11798692.
    Abstract:
    OBJECTIVE: To compare the bioavailability of three brands of omeprazole capsule (Losec, Aoke-Changzhou No.4 Pharm, Omeprazole-Sanye Pharm) and their effects on 24 hour intragastric pH in healthy volunteers. METHODS: With crossover design (washout period of 7 days), 18 healthy volunteers (12 men, 6 women) were randomly divided into three groups. Each subject was given the three different brands of omeprazole capsule 40 mg respectively. RESULTS: The pharmacokinetic study revealed that Losec had an advantage over other two brands of omeprazole capsule in that it was absorbed more rapidly and to a greater extent, resulting in higher plasma concentration and longer staying time in blood. It also showed the shortest latent time in elevating intragastric pH (2.53 hours), the largest net increment in mean gastric pH (3.37), and the greatest prolongation of time with pH > 4 (15.3 hours) among the three products. CONCLUSION: The three brands of omeprazole capsule are significantly different with respect to their pharmacokinetic process and effects on 24 hour intragastric pH profile. Losec is superior to other two brands of omeprazole capsule in view of its better bioavailability, quicker onset of action, more potent and lasting antisecretory effect.
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