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  • Title: [Protective effect of c-fos antisense oligonucleotides on brain damage induced by glutamate].
    Author: Yue S, Luo Z, Feng D.
    Journal: Zhonghua Yi Xue Za Zhi; 2001 Feb 10; 81(3):145-9. PubMed ID: 11798865.
    Abstract:
    OBJECTIVE: To investigate the relation between glutamate neurotoxicity and c-fos gene expression. METHODS: c-fos antisense oligonucleotides (AS ODN) was injected into the right lateral ventricles of 9 SD rats to block the c-fos gene expression in brain tissue. c-fos sense oligonucleotides (S ODN) was used a control. The numbers and morphology of neurons in both cerebral cortex and hippocampal CA1 were detected by MIAS-300 image analysing instrument. c-fos gene expression in brain was observed by immunohistochemical method. The content of water and electrolytes in the brain tissue and Ca(2+) in the synapse were measured. RESULTS: The c-fos AS ODN blocked the c-fos gene expression and reduced the content of both water and sodium in brain tissue and Ca(2+) in symptosome, thus alleviating the morphological damage in neuron. S ODN did not have such effect. CONCLUSION: c-fos gene expression plays an important role in mediating the effect of glutamate neurotoxicity. Blocking the c-fos gene expression could antagonize glutamate neurotoxicity.
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