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  • Title: CD56-Positive cutaneous lymphoma with multicentric Castleman's disease-like systemic manifestations.
    Author: Amo Y, Ogata F, Okabe S, Yonemoto K, Katsuoka K.
    Journal: J Dermatol; 2001 Dec; 28(12):746-52. PubMed ID: 11804073.
    Abstract:
    We report a 55-year-old Japanese male with CD56+ cutaneous lymphoma. The patient had multiple cervical lymphadenopathy, a red nodule on his neck, and parotid gland nodularity. Histologic features of the biopsied cervical lymph node showed follicular hyperplasia with numerous plasma cells. A biopsied skin specimen of the nodule on his neck demonstrated dense infiltration of atypical large lymphocytes into the dermis. Immunohistochemical study of this specimen revealed CD3+, CD4+, and CD56+ expression in the majority of neoplastic cells. Polymerase chain reaction assays for the detection of Epstein-Barr virus sequences were positive for lymph node and skin DNA. Laboratory examinations showed polyclonal gammopathy, pancytopenia, and high serum interleukin-6 levels. These clinical and histological findings resembled those of multicentric Castleman's disease.
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