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  • Title: [Experimental data on hygienic norms for antibiotics of the tetracycline group].
    Author: Zel'tser IZ, Balabanova EL, Lapchinskaia AV, Baru RV, Vil'shanskaia FL.
    Journal: Antibiotiki; 1975 Sep; (9):793-8. PubMed ID: 1180532.
    Abstract:
    Toxicity of tetracyclines was studied experimentally on different species of laboratory animals. It was shown that tetracycline, oxytetracycline and chlortetracycline were close by their chemical structure and physico-chemical properties, as well as by the main toxicity parameters, i.e. acute toxicity, cumulative activity, skin-irritating and sensitizing effect. Under the conditions of subacute experiments the above 3 antibiotics induced evenly pronounced one direction changes in animals. The data obtained during the experiments provided recommendation of the level of 0.1 mg/m3 as the maximum allowable concentration (MAC) of oxytetracycline and chlortetracycline, i.e. the same level as the previously recommended for tetracycline.
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