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  • Title: [Study on transplantable, melanin containing hamster papova virusinduced skin tumours in Syrian hamster (author's transl)].
    Author: Bender E, Graffi A, Niezabitowski A, Wildner GP, Schneiders F.
    Journal: Arch Geschwulstforsch; 1975; 45(3):244-54. PubMed ID: 1180674.
    Abstract:
    A melanin containing skin tumour of trichoepitheliomatic character, induced by a virus some 40 nm large, is described showing neither infiltrative nor metastasizing growth. The multiple, flat, mostly confluent tumour nodes appear in all parts of the skin, especially in dorsal skin, at the chin, eyes, and ears. The tumours are mostly blue black as a result of hemosiderin and melanin deposits; these pigmentations occur in connective-tissue cells, the tumour cells and the abounding keratinizing cysts. The blastomic character of these tumours, which in part are reminiscent of tricho-epitheliomas, can be demonstrated by transplantation experiments, in which with increasing number of passages are observed a decrease of latent period, disappearance of pigment formation, and increase in histologic de-differentiation.
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