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  • Title: [The chemotactic response of gingival fibroblasts and periodontal ligament cells to interleukin-8].
    Author: Luan Q, Toshiaki S, Katsunori M.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2001 Jan; 36(1):40-1. PubMed ID: 11812302.
    Abstract:
    OBJECTIVE: To evaluate the chemotactic response of gingival fibroblasts and periodontal ligament cells to interleukin-8. METHODS: The passage 6 cultured gingival fibroblasts and periodontal ligament cells (2.5 x 10(8) cell/L, respective) were placed in the upper compartment of the Transwell cell culture chamber. The lower compartment contained IL-8 with the concentrations of 10(-10), 10(-9), 10(-8), 10(-7) mol/L, respectively. Incubation was at 37 degrees C in an atmosphere of 95% air and 5% CO2 for 24 h. The number of migrated cells were counted under high power fields. RESULTS: IL-8 at concentrations ranged from 10(-9)-10(-7) mol/L promoted the chemotactic movement of gingival fibroblasts in a dose-dependent manner. However, at the same IL-8 concentrations the chemotactic movement of periodontal ligament cells was not elevated. CONCLUSION: IL-8 may play its role in regulating chemotaxis of gingival fibroblast.
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