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  • Title: [Research on expression of human papillomavirus type 16 and telomerase in oral lesions].
    Author: Patiman, Zhang Z, Cao J.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2001 Mar; 36(2):119-21. PubMed ID: 11812320.
    Abstract:
    OBJECTIVE: To define a correlation between human papillomavirus (HPV) type 16 and telomerase activity during the carcinogenesis of oral mucosa. METHODS: HPV16 DNA and human telomerase reverse transcriptase (hTRT) mRNA were detected in 82 cases of paraffin embedded tissues including 7 cases of normal oral mucosa, 7 cases of hyperplasia lesions, 30 cases of oral dysplasia lesions and 38 cases of oral squamous cell carcinomas (OSCCs) by PCR and in situ hybridization (ISH) respectively. RESULTS: HPV16DNA was positive in 14.3% (1/7) of normal oral mucosa, 42.9% (3/7) of hyperplasia lesions, 66.6% (20/30) of dysplasia lesions and 92.1% (35/38) of OSCCs. hTRTmRNA was detectable in 30.0% (9/30) of oral dysplasia lesions and 81.6% (31/35) of OSCCs while normal oral mucosa and hyperplasia lesions were negative. Expression of HPV16DNA and hTRTmRNA were co-ordinate in 67.0% (55/82) cases. CONCLUSIONS: HPV16 infection may play an important role in carcinogenesis of oral mucosa by activation of telomerase.
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