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  • Title: Studies on deoxyribonucleoproteins. IX. Subfractions of deoxyribonucleoproteins from rat and mouse liver.
    Author: Harbers E, Hollandt H, Eilers-König C, Schneider R, Struttmann C, Warnecke P.
    Journal: Hoppe Seylers Z Physiol Chem; 1975 Jun; 356(6):671-5. PubMed ID: 1181267.
    Abstract:
    By carrier-free continuous electrophoresis, deoxyribonucleoprotein from rat and mouse liver could be separated into two subfractions. The more anodic fraction (DNP I), comprising 5 - 8 per cent of the total, contains fewer proteins (two types of histones only). [3H]Cyclophosphamide caused in vivo a 2.5 times higher alkylation of the DNA in in DNP I than of the DNA in DNP II. These and additional results led to the suggestion of a structural model with DNP I as a spacer in the deoxyribonucleoprotein fiber.
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