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  • Title: 4-Anilino-3-cyanobenzo[g]quinolines as kinase inhibitors.
    Author: Zhang N, Wu B, Wissner A, Powell DW, Rabindran SK, Kohler C, Boschelli F.
    Journal: Bioorg Med Chem Lett; 2002 Feb 11; 12(3):423-5. PubMed ID: 11814812.
    Abstract:
    A series of 4-anilino-3-cyanobenzo[g]quinolines was prepared as potent kinase inhibitors. Compared with their bicyclic 4-anilino-3-cyanoquinoline analogues, the tricyclic 4-anilino-3-cyanobenzo[g]quinolines are less active against EGF-R kinase, equally active against MAPK kinase (MEK), and more active against Src kinase. For Src kinase inhibition, the best activity is obtained when both the 7- and 8-positions are substituted with alkoxy groups. Several of these kinase inhibitors show potent growth inhibitory activity in tumor cells.
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