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  • Title: The effect of osmolality changes on gastric mucosal endogenous prostacyclin levels in drug-induced experimental ulcer model of rat.
    Author: Gharzouli K, Balint GA, Galfi M, Rimanoczy A, Juhasz A.
    Journal: Exp Toxicol Pathol; 2001 Oct; 53(5):409-11. PubMed ID: 11817111.
    Abstract:
    Osmolality changes evoked with intragastric administration of natural honey or mannitol, significantly decreased the gastric ulceration of rats induced by indomethacin. Together with this effect, a parallel increase was detectable in the mucosal level of endogenous prostacyclin. Although many processes may be involved in this phenomenon, the authors explain their data with a stimulating effect on gastric mucosal microcirculation due to osmolality changes.
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