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  • Title: Anticonvulsant and neurotoxicity evaluation of 5-(un)-substituted isatinimino derivatives.
    Author: Pandeya SN, Sriram D, Yogeeswari P, Stables JP.
    Journal: Pharmazie; 2001 Nov; 56(11):875-6. PubMed ID: 11817174.
    Abstract:
    Various Schiff bases were prepared by reacting 5-(un)-substituted isatin with some heterocyclic compounds, viz., N-[4-(4'-chlorophenyl-thiazol-2-yl] semicarbazide, 3-amino-2-methylmercaptoquinazolin-4-one, 3-(4'-pyridyl)-4-amino-5-mercapto-4(H)-1,2,4-triazole and 4-(4'-chlorophenyl)-6-(4"-methylphenyl)-2-aminopyrimidine. The compounds were evaluated for anticonvulsant and neurotoxic properties. The compound 3-(3',4'-dihydro-2'-methylmercapto-4'-oxoquinazolin-3'-yl) iminoisatin (3) emerged as the most active analogue showing anti-MES and anti-PTZ activities better than valproic acid. All the compounds showed lower neurotoxicity than phenytoin and carbamazepine.
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