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  • Title: Recent advancements in the treatment of chronic myelogenous leukemia.
    Author: O'Dwyer ME, Mauro MJ, Druker BJ.
    Journal: Annu Rev Med; 2002; 53():369-81. PubMed ID: 11818480.
    Abstract:
    Chronic myelogenous leukemia (CML) is a clonal hematopoetic stem cell disorder characterized by the Philadelphia chromosome and resultant production of the constitutively activated Bcr-Abl tyrosine kinase. Characterized clinically by marked myeloid proliferation, it invariably terminates in an acute leukemia. Conventional therapeutic options include interferon-based regimens and stem cell transplantation, with stem cell transplantation being the only curative therapy. Through rational drug development, STI571, a Bcr-Abl tyrosine kinase inhibitor, has emerged as a paradigm for gene product targeted therapy, offering new hope for expanded treatment options for patients with CML.
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